All brand new, unopened. Checked on Boots website and one box of 20 cartridges is £25. I have a total of 72 all in sealed, unopened blister packs. I've managed to stop smoking and don't need these any more. Would cost over £85 to buy. The only reason the cartridges are not in the original pack is because I kept them all in a plastic box, and the original boxes were too bulky. note, on the photo, the cartridges are the third image down. A close up shows they are in date until Jan 2022.